The train is believed to have derailed in Dalfsen in the northern part of the Netherlands about 75 miles east of Amsterdam.
It is thought to have collided with a hydraulic maintenance crane that was pruning nearby trees at around 8am local time.
Four carriages of the train – operated by Arriva – were left lying in a field beside the railway.
The Mayor Han Noten has already spoken on local broadcast media to say that at least one person has died.
Mr Noten said: “At around 9pm the train left from Dalfsen to Ommen. It is in the middle of the field, so we do not know so much.
“There are multiple injuries. At present we are engaged in the rescue operation and that can take some time.
“It”s fortunately not the busiest train, so it will be easy in terms of numbers, but with the dead and the wounded, the consequences are dramatic now.”
Eyewitnesses told Dutch News that the crane had waited for a first train – and then attempted to cross – but was hit by a train coming from the opposite direction.
Another local broadcaster also reported today that the driver was killed in the collision.
A tweet (above) appears to show the location of the crossing in relation to where the carriages now lie in the wreckage.
The tragedy follows a train crash in Bavaria in Germany earlier this month that killed 11 and injured 80.
The Dutch Safety Board has already launched an investigation into the accident.