Both nations are at loggerheads over the bloody conflict in Syria, with relations reaching their lowest ebb since the Cold War.
The war-ravaged country is increasingly seen as a key battle ground, with both superpowers picking sides with opposing forces.
Russia has backed president Bashar Assad’s regime, while America has thrown its firepower behind the Syrian opposition in the bloody and brutal fight for power.
With conflict appearing to reach deadlock, deputy prime minister of Turkey, Numan Kurtulmus, said the two warring nations are on a collision course for global war unless there is peace.
But according to Russian newspaper Vzglyad, American “total control” of Syria is “impossible”.
Vlad’s advanced missile defence systems would stop US Air Force airstrikes in their tracks, the paper claims.
It said: “In Syria, America”s greater engagement even in the form of a total control over [Syrian airspace] is impossible due to the presence of the Russian Aerospace Forces and air defense systems.”
Evgeny Satanovsky, head of the Moscow-based Middle East Institute, told the newspaper US wouldn’t risk going into direct conflict with Russia.
He said: “Even if the US Air Force launches airstrikes against Bashar al-Assads forces, it will use cruise missiles.
“In this case, the airstrikes will become a test for our S-300 system capable of destroying this type of weapons.”