The victim has been named as 27-year-old Jodie Wilkinson and flowers, cards and candles have been left near the scene paying tribute to “a loving aunt and sister.”
A 25-year-old man injured in the incident was treated for stab wounds but later discharged from hospital.
Police said a total of five men were now in custody after being arrested in connection with the incident.
They said an 18 and a 20-year-old had been detained tonight after the earlier arrests of three other suspects – one aged 22, the others both 25.
Officers were called to the scene in Newcastle-upon-Tyne after receiving reports from paramedics that two people had been taken to hospital with stab wounds.
The scene, close to St James” Park football stadium, remains cordoned off as forensic investigators conduct a finger-tip search of the area.
Chief Superintendent David Felton of Northumbria Police said: “Firstly, our thoughts are with the friends and family of Jodie Wilkinson at this tragic time.
“I want to reassure them that we are doing all we can to find and arrest those responsible for her death and make sure they get the justice they deserve.
“We believe that this has been an altercation between a group of people who may have been known to each other and not a random attack.
“Although the motive behind the attack is still being investigated we believe it potentially could have been some kind of dispute and I want to reassure the community that we do not believe there is any risk to the general public.
“That said, we will have extra officers in the area today and over the coming days to reassure people and provide a visible policing presence in the area. Please speak to them if you have any concerns or want to pass any information on.”
Ch Supt Felton urged witness to contact police with any information.
He said: “We really need the public”s help and in particular the help from the local community. If you don”t want to speak to police then that”s fine, please use Crimestoppers because it is completely anonymous. Information can be passed to them on their number without giving your name or any details and there is a reward for helping us.
“Anyone who knew Jodie or who has any information at all then please do the right thing and speak to us, help us bring those responsible for her death into custody.”
In a statement released by Jodie”s sister, Amy, she said: “Jodie was a devoted aunty and loving sister. She would do anything for anyone and we”ve got no idea why someone would take her life. All we ask is at this stage anyone with any information, no matter how small, to please come forward and assist the police.”
Newcastle City Council leader Nick Forbes said: “Many people will have been shocked and saddened and by this horrific incident and my sympathies are with the friends and family of the victim.
“The people involved in this incident were known to each other and while there is no risk to the public I am pleased that the police have stepped up their help and reassurances to our local community.”
A nearby church is holding a special service on Sunday morning for members of community affected by the incident.