The A38 in Derbyshire is closed in both directions between Alfreton and J28 of the M1 following a lorry fire.
Commuters are being advised there are major delays on the route with emergency services telling people to avoid the area.
Parents in the area are being advised there will delays in picking up their children from local schools.
Delays are now more than an hour on the M1 towards Junction 28.
A spokesman for Derbyshire Police said: “The A38 remains closed in both directions from Alfreton to the junction with the M1.
“It is expected that the road will remain closed into the early evening.”